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Term Papers on Neurospora Crassa

Term Paper TitleNeurospora Crassa
# of Words613
# of Pages (250 words per page double spaced)2.45

Neurospora Crassa


            Throughout our science education, as students we have always wondered how genes are regulated in a given organism. To better understand biological processes in organisms we can take a look at a biological circuit, a term borrowed from electrical engineering that illustrates the interconnections among proteins or genes (1). Circuits can describe connections needed to regulate a single gene or an entire genome. Through a circuit we can visualize important components and reactions that are otherwise difficult to perceive. In this short study the organism of Neurospora crassa will be farther analyzed. For the first time, it is now possible to place a particular biological circuit like those describing carbon metabolism, transcription, cell cycle, or the biological clock in simple eukaryotes in a larger context, and to examine the coupling of these circuits (12).  In this report, we look at a network of reactions for the regulation of the qa cluster . As understood, the qa cluster is composed of five genes and two regulatory genes, as seen in the biological circuit Figure 1.1. “Three of the genes, qa-2, qa-3, and qa-4, in the cluster encode enzymes involved in the catabolism of quinic acid. One gene, qa-y, encodes a permease allowing quinic acid into the cell, and another gene, qa-x, encodes an unknown function. All seven genes in the cluster are transcriptionally activated by the product of qa-1F, and the activator is repressed by the product of qa-1S. The cluster is glucose- and sucrose-repressed.” If this is true then when qa-1F^p is turned off then nothing should be produced and also if abundant portions of qa-1S^p are present then PCA should be present in limited quantities. These simple experiments will allow students such as myself to gain a better understand of what is going on visually and not only in text. Although these experi...

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